Because pathological intimal lesion such as plexiform lesion is a hallmark of pulmonary arterial hypertension in human, further analyses to explore a role of endothelial FAM13A in the formation of intimal lesions are required to validate FAM13A as a feasible pharmacotherapeutic target for the treatment of pulmonary arterial hypertension. The gene discussed is FAM13A; the disease is pulmonary arterial hypertension.