ARHGAP1 and cystic fibrosis: FAM13A is known to harbor a Ras-homologous GTPase-activating protein (RhoGAP) domain that is important for proliferation and survival in lung adenocarcinoma cell A549 [24], and this domain could activates RhoA which can affect actin cytoskeleton and promotes epithelial-to-mesenchymal transition in cystic fibrosis lung [8].