With regard to total adiponectin, three of a total of seven prospective studies have reported an inverse association with the risk of colorectal cancer, and the aforementioned meta-analysis replicated a significant inverse association (OR = 0.716; 95% CI, 0.606–0.847) without significant heterogeneity (P = 0.105) [32]. This evidence concerns the gene ADIPOQ and colorectal cancer.