ADIPOQ and obesity due to melanocortin 4 receptor deficiency: Compared to non-carriers in the lowest quintile of total adiponectin, carriers of the obesity risk A allele in the same quintile showed a considerably elevated risk of colorectal cancer with the multivariate adjusted OR of 2.54 (95% CI, 1.36–4.75), while the corresponding OR was 2.18 (95% CI, 1.14–4.16) for HMW adiponectin.