Subsequently, a number of SNPs within the first intronic region of the FTO gene, e.g. rs9939609, have been investigated in relation to the risk of obesity-associated malignancies [5–7], and some studies have reported a significant association with the incidence of breast [8,9], endometrial [10,11], and pancreatic cancers [12]. This evidence concerns the gene FTO and obesity due to melanocortin 4 receptor deficiency.