However, a meta-analysis [19] shows that the diagnostic efficiency of AFP ≥ 200 ng/mL may be higher, partly because some of the early HCC [20] may be missed in the population with low concentration of AFP (20 to 200 ng/mL) if 400 ng/mL is still used as the criteria in HCC screening. This evidence concerns the gene AFP and hepatocellular carcinoma.