NFE2L2 and cancer: For example, increased NRF2 has been shown to suppress reactive oxygen species (ROS) formation, enhancing tumorigenesis in Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (K-Ras)–, v-raf murine sarcoma viral oncogene homolog B1 (B-Raf)–, and MYC Proto-Oncogene (Myc)-driven cancers [16].