The human genes coding for β5i and β1i map to chromosome 6 precisely between the DNA sequences coding for human leucocyte antigen (HLA)-DQ, HLA-DM and Transporter 1 ATP Binding Cassette Subfamily B Member (TAP) 1 and 2 (S2 Fig), genes known to be major determinants of antigen presentation and predisposing to autoimmune diseases, including type 1 diabetes [58]. The gene discussed is HLA-DMA; the disease is autoimmune disease.