In multivariate Cox proportional hazards modelling, being dosed ≥2.03 mg/cm2 retained its prognostic significance for both PFS (HR 2.28, 95% CI 1.23−4.09, P = 0.004) and OS (HR 2.53, 95% CI 1.41−4.93, P = 0.002, see Table3) when also considering advanced age, male sex, LDH, positive BRAF status, and sarcopenia. Here, BRAF is linked to sarcopenia.