P4HA1 and neoplasm: P4HA1 expression is induced in hypoxia by the hypoxia‐inducible factor 1 (HIF‐1) (Gilkes et al., 2013a), which regulates several pathways involved in tumor progression (reviewed in Balamurugan, 2016), such as EMT, angiogenesis, invasion, inflammation, and tumor metabolism, including the glycolytic pathway.