Further, our results show that P4HA1 knockdown reduced the secretion of CTHRC1, an important mediator of melanoma cell migration and invasion, in vitro and its deposition around tumor blood vessels in vivo, suggesting that this angiogenesis‐promoting molecule may also play an important role in P4HA1‐regulated neovascularization. This evidence concerns the gene P4HA1 and melanoma.