As we found P4HA1 knockdown to reduce the secretion of CTHRC1 in melanoma cells in vitro, and our previous results have shown that CTHRC1 is localized in the blood vessels in human melanomas (Eriksson et al., 2016), we further studied the expression of CTHRC1 in the xenograft tumors (Fig. S11F–J). Here, P4HA1 is linked to melanoma.