The expression of P4HA1, RHOC, SORT1, CD63, and CDK2AP1 remained significantly associated (P < 0.05) with shorter survival and EGFR, PTBP3, and CXADR with longer survival after adjusting for Breslow’s thickness in bivariable Cox regression models, suggesting that these genes are independent candidate markers of melanoma patient survival. This evidence concerns the gene CD63 and melanoma.