JPH2 expression is down-regulated in animal and human cardiomyopathies,5,6,11,20–25 and its localization altered: while JPH2 is distributed in a regular striated pattern in healthy myocytes, the protein forms aggregates in failing cells,7 leaving areas devoid of JPH2 which most likely correlate with areas of extensive T-tubule remodelling. The gene discussed is JPH2; the disease is cardiomyopathy.