A significant reduction in the area of collagen gels was observed in the ET‐1‐treated groups, compared with that of the untreated controls (Figure 1G), which is consistent with the results of previous studies.17, 28, 29 Thus, our data suggest that ET‐1 induced IOP elevation and collagen deposition mimics the pathological features of POAG. This evidence concerns the gene EDN1 and open-angle glaucoma.