Our results agree with other studies where WNT5A has inhibited canonical WNT signalling in the development of cancer.51 Other groups have reported that WNT5A blocks transcriptional activity of β‐catenin and does not directly impact levels of pGSK3B or β‐catenin protein levels.40, 52, 53 Our results demonstrate a more upstream effect as we observed WNT5A to reduce levels of pGSK3B, which coincided with decreased levels of total b‐catenin. The gene discussed is WNT5A; the disease is cancer.