TWIST1 and neoplasm: Studies have reported that cisplatin is capable of inducing cell apoptosis, which is caused by cross‐linking of intracellular DNA and DNA damage leading to regression of tumours; however, apoptosis can also lead to increased expression of EMT‐inducible factors (such as Twist and Snail) and treatment failure.29 These findings indicate that the formation of cisplatin resistance is associated with EMT.