The comparison of effects of non‐O blood type and acquired CLD‐related factors in our series of patients with portal hypertension may provide an explanation for the lack of an association between ABO blood type and PVT: Although the effect of non‐O blood type on VWF levels attained statistical significance, it explained only about 1% of the variance in VWF (r2 = .01), which is substantially less as compared to the general population (15.4%46). The gene discussed is VWF; the disease is portal hypertension.