CYP27B1 and hypercalcemia disease: Thus, the induction of CYP27B1 in these extrarenal tissues by cytokines and the failure of CYP27B1 in these tissues to respond to the increased circulating levels of 1,25(OH)2D and calcium account for the hypercalcemia often found in granulomatous diseases such as sarcoidosis and lymphomas [24, 31].