AKI, acute kidney injury; HTN, hypertension; DM, diabetes mellitus; CVA/TIA, cerebrovascular accident/transient ischemic attack; GFR, glomerular filtration rate; PCI, percutaneous coronary intervention; ACEi/ARB, angiotensin-converting enzyme inhibitor/angiotensin receptor blocker; NSAID, non-steroidal anti-inflammatory drug. The gene discussed is ACE; the disease is diabetes mellitus.