VEGFA and macular retinal edema: A literature search using the key words “anti-VEGF agent, intraocular pressure, ranibizumab, drug volume, 0.3 mg, 0.5 mg ml, age-related macular degeneration, macular edema, sustained IOP rise, long-term IOP rise” on PubMed, Scopus, and the Cochrane Database on 11th May 2019 failed to reveal any study that looks at the volume of injected ranibizumab and IOP rise; logically, a higher volume would mean a great probability of short-term IOP spikes, but we demonstrate courtesy multivariate analysis that this influences long-term IOP rise too.