TYRO3 and arthritic joint disease: It seems, therefore, that activated Tyro3 may be responsible for stimulating synovial hypertrophy, cartilage destruction, and bone erosion, suggesting a dual antithetic role for the TAM axis in arthritis depending on which receptor is activated, i.e., an anti-inflammatory effect in case of Axl or Mer but proerosive if Tyro3 is triggered.