For LGDH syndrome, the target genes were also particularly involved in 8 signaling pathways including cytokine-cytokine receptor interaction (hsa04060), focal adhesion (hsa04510), Jak-STAT signaling pathway (hsa04630), TGF-beta signaling pathway (hsa04350), renal cell carcinoma (hsa05211), pancreatic cancer (hsa05212), colorectal cancer (hsa05210) and ErbB signaling pathway (hsa04012). The gene discussed is EGFR; the disease is familial pancreatic carcinoma.