Notably, the target genes in SSDH group specifically linked to 8 signaling pathways including ubiquitin-mediated proteolysis (hsa04120), p53 signaling pathway (hsa04115), regulation of actin cytoskeleton (hsa04810), cell adhesion molecules (CAMs) (hsa04514), purine metabolism (hsa00230), Wnt signaling pathway (hsa04310), glioma (hsa05214) and epithelial cell signaling in Helicobacter pylori infection (hsa05120). Here, ALDH5A1 is linked to central nervous system cancer.