During the preparation of our manuscript, the existence of N6-hmA in mammalian genomes as well as its accumulation in lung carcinoma tissues was reported and ALKBH1 was shown to convert N6-mA to N6-hmA in vivo.30 With these intriguing results, further studies are needed to delineate the biological function and regulatory roles of N6-hmA generated by ALKBH1. The gene discussed is ALKBH1; the disease is lung carcinoma.