Among these kinases, 6 (RPS6KB2, DSTYK, TBRG4, CDK4, POLR2E, FASTKD5) and 4 (STK26, PAK1, EPHB2 and JAK3) were consistently up- or down-regulated, respectively, in the metastatic lines of at least two pairs of melanoma cells (Figs. 4b and S7). The gene discussed is POLR2E; the disease is melanoma.