IQGAP1’s RasGAP C-terminal (RGCT) domain associates with the exocyst complex proteins Sec3 and Sec8, and this association is necessary for the formation of mature invadopodia18, actin-rich protrusions used by tumor cells to degrade and invade through the extracellular matrix19. The gene discussed is IQGAP1; the disease is neoplasm.