Studies have shown that AS1DHRS4 recruits epigenetic machinery, including DNA methyltransferases (DNMTs) and histone modifiers, to the DHRS4 gene cluster to regulate expression of DHRS4. A decrease in AS1DHRS4 has been associated with increased metastatic capacity in clear cell renal carcinoma via lesser recruitment of DNMTs to the DHRS4 gene cluster59. This evidence concerns the gene DHRS4-AS1 and clear cell renal carcinoma.