Factors that regulate gene transcription, such as TAF13, NKX2–5, and NKX2-1, pro-apoptotic genes, such as DNASE1, CASP3, PPT1, and FZD6, and several inhibitors of oncogenic signaling, migration and metastasis, namely FZD6, RECK, and SSBP1, were significantly hypermethylated explicitly in invasive breast cancer (Fig. 2B). Here, CASP3 is linked to invasive breast carcinoma.