Interestingly, among genes associated with hypomethylated promoters, there was a cancer promoting gene PLAU. According to gene ontology (GO) function and KEGG pathway analysis using DAVID Knowledgebase (Fig. S1), PLAU is categorized into “transcriptional misregulation,” the most prominent pathway of genes with hypomethylated promoters in ADH versus healthy tissue. This evidence concerns the gene AVP and cancer.