Dysregulated AMPK/SIRT1 and PGC-1α pathway, which could directly affect mitochondrial metabolism and biogenesis, led us to evaluate the RNAseq data for the mitochondrial genes such as MRPL16 and PMAIP1 in the AMD RPE as compared to normal RPE. The gene discussed is PPARGC1A; the disease is age-related macular degeneration.