IGF1 and age-related macular degeneration: The level of phospho p70 was induced by IGF-1 after 15 minutes incubation followed by a decrease after 30 minutes in normal RPE, in AMD RPE; however, the phsopho p70 was significantly higher in the absence of IGF-1 and was sustained until 1 h after incubation with IGF-1 (Fig. 3A,D).