CNN3 and cervical carcinoma: Considering that HPV oncoproteins act as drivers in the initiation and development of cervical cancer, we examined the effect of HPV16E5/E6/E7 on CNN3 expression in cervical cancer cell lines, SiHa and CaSki, and found decreased expression of CNN3 protein in both cells when they were transfected with E5 and E6/E7 siRNA, respectively (Fig. 1D).