To confirm CNN3 promoting the metastasis of cervical cancer, we intravenously injected SiHa cells stably transfected with sh-CNN3 or sh-NC into scid mice via tail vein (n = 6 in each group), and found that the luminescence intensity was markedly decreased (Fig. 2D,E) and the numbers of visible lung metastases were significantly lower in the sh-CNN3#1 group at week 12 after transfection, compared to the controls (Fig. 2F,G), suggesting that CNN3 promotes the growth and metastasis of cervical cancer in vivo. Here, CNN3 is linked to cervical carcinoma.