To confirm CNN3 promoting the metastasis of cervical cancer, we intravenously injected SiHa cells stably transfected with sh-CNN3 or sh-NC into scid mice via tail vein (n = 6 in each group), and found that the luminescence intensity was markedly decreased (Fig. 2D,E) and the numbers of visible lung metastases were significantly lower in the sh-CNN3#1 group at week 12 after transfection, compared to the controls (Fig. 2F,G), suggesting that CNN3 promotes the growth and metastasis of cervical cancer in vivo. The gene discussed is CNN3; the disease is cervical cancer.