Using univariate Cox regression analysis, we found that depth of tumor infiltration (p = 0.03), local lymph node metastasis (p < 0.001), clinical stage (pTNM status, p = 0.001), tumor grade (p = 0.044), and SIRT1 expression levels (p < 0.001) were significantly associated with the overall survival of GC patients. Here, SIRT1 is linked to gastric cancer.