CCR3 and nonpapillary renal cell carcinoma: Furthermore, knockdown of CCR3 by siRNA or SB328437 weakened the enhanced proliferation, invasion, migration, and tumorigenicity in ccRCC cells mediated by gankyrin and inhibited the gankyrin-mediated apoptosis of ccRCC cells (Fig. 3h–o;, Supplementary Fig. S3c–g and S3l).