First, CCL24 was upregulated in the blood serum of patients with localized ccRCC compared with healthy individuals, and the highest concentration of CCL24 was observed in patients with metastatic ccRCC (Fig. 4f), which indicated that the CCL24 level in blood serum is positively associated with disease progression. The gene discussed is CCL24; the disease is nonpapillary renal cell carcinoma.