PSMD10 and nonpapillary renal cell carcinoma: An orthotopic ccRCC model was established through the injection of luciferase-expressing pazopanib-resistant 786-O (786-O-PR) cells (the pazopanib resistance was confirmed as shown in Supplementary Fig. S6a, c) without or with gankyrin knockdown (gankyrin-KD) into the subcapsular kidney of NOD/SCID mice.