PSMD10 and nonpapillary renal cell carcinoma: Contrary to the above-mentioned results for gankyrin overexpression, pazopanib treatment resulted in more apoptotic events and decreased proliferation in the gankyrin-knockdown 786-O cells compared with those found in the control cells (Fig. 2e, f), which suggests that gankyrin-knockdown ccRCC cells are sensitive to pazopanib.