Hence, although this study preliminarily elucidated the molecular mechanisms through which gankyrin regulates the progression of ccRCC (Fig. 7f), our further study will determine whether gankyrin can recruit inflammatory immune cells and mediate antitumoral immunity in ccRCC, and these findings will provide new therapeutic strategies for advanced or metastatic ccRCC. Here, PSMD10 is linked to nonpapillary renal cell carcinoma.