Second, in vitro assay results demonstrated that downregulation of CCL24 by siRNA or a neutralizing antibody alleviated the gankyrin-mediated promotion of the proliferation, invasion, migration, and pazopanib resistance ccRCC cells and the gankyrin-mediated inhibition of ccRCC cell apoptosis (Fig. 3h–m; Supplementary Fig. S3c–g). This evidence concerns the gene CCL24 and nonpapillary renal cell carcinoma.