POLE and central nervous system cancer: Although the Msh2, Msh6, Mlh1, and Pms2 IHC panel is used to screen colorectal cancer, mutations in other DNA repair genes have also been reported in post-TMZ hypermutated gliomas, including MSH4, MSH5, MLH3, PMS1, POLE, and POLD1 [4, 11, 14, 28].