For example, increased plasma CRP was associated with reduced functional connectivity in a widely distributed network including the ventral striatum, parahippocampus, amygdala, orbitofrontal cortex, insula, and posterior cingulate cortex (PCC) [24], while plasma and cerebrospinal fluid CRP were associated with chemical shift imaging measures of basal ganglia glutamate in 50 medication-free MDD outpatients [25]. Here, CRP is linked to major depressive disorder.