CHIT1 serum concentration correlates with the progression or the severity of several diseases (sarcoidosis, rheumatoid arthritis, ankylosing spondylitis, uveitis, idiopathic pulmonary fibrosis, scleroderma-associated interstitial lung diseases, and chronic obstructive lung diseases), suggesting a potential use of CHIT1 as an AKU biomarker [20, 21]. Here, CHIT1 is linked to ankylosing spondylitis.