It is also becoming increasingly apparent however, since specific cancer-related proteins, such as the tumor suppressors p53 [4], retinoblastoma protein (Rb) [5], the paracrine/autocrine signaling molecule parathyroid hormone-related protein (PTHrP) [3], CD44 [6], and EGFR [7], have been reported to transport through the nuclear pore to either activate or deactivate relevant signaling cascades. The gene discussed is PTHLH; the disease is cancer.