We found the effects on body weight, SBP, ALT and eGFR values were better in SGLT2 inhibitors than DPP4 inhibitors throughout a series of subgroup analyses with HbA1c > 7 or ≤ 7%, ALT > 1× or ≤ 1× ULN, with or without a history of treatment failures of > 1 anti-diabetes medications, and with BMI ≥ 27 kg/m2 or < 27 kg/m2. Here, DPP4 is linked to diabetes mellitus.