We undertook to investigate the expression and relationship of the HCV core proteins – P21 and Bcl-2 – in tissues of patients with hepatitis C and cirrhosis; the positive expression of HCV core protein and mutant P21 is mainly located in the nucleus; for Bcl-2, the positive expression was mainly located in the cytoplasm; furthermore, the positive expression rate of P21 was only 13%, and the positive expression rate of Bcl-2 was 95.7%. This evidence concerns the gene BCL2 and hepatitis C virus infection.