In Module 1, we screened eight pathways according to P < 0.01 and FDR < 0.01; these mainly included the apoptotic pathway (hsa04210); TNF signaling pathway (hsa04668); p53 signaling pathway (hsa04115), etc. In Module 2, we screened 23 pathways according to P < 0.01 and FDR < 0.01; these mainly included the ErbB signaling pathway (hsa04012); glioma pathway (hsa05214); chronic myeloid leukemia pathway (hsa05220); endometrial cancer pathway (hsa05213), etc. The gene discussed is TP53; the disease is central nervous system cancer.