The aim of the present study was to explore the possible association of three IL-10 gene promoter SNPs -592C/A (rs1800872), −819C/T (rs1800871) and -1082A/G (rs1800896), and their related haplotypes with susceptibility to PEX, PEXG and POAG eye disorders in well-characterized patient groups originating from Iran. The gene discussed is IL10; the disease is open-angle glaucoma.