ABCG2 and bacterial infectious disease: Notably, LPS strongly suppressed the transcriptional activity of the chicken Abcg2 promoter, mRNA expression levels, and the transport function of BCRP, thereby suggesting that the net absorption of BCRP substrate drugs increases when bacterial infection occurs in chicken; although this might be favorable in many cases, it bears the risk of undesirable side-effects of the drug with a small margin of safety [48,49].