Most cases of ARVC are attributed to mutations in desmosomal genes, including plakoglobin (JUP), plakophilin-2 (PKP2), desmoplakin (DSP), desmoglein-2 (DSG2) and desmocollin-2 (DSC2) [4]. The gene discussed is DSC2; the disease is arrhythmogenic right ventricular cardiomyopathy.