In summary, this study revealed that in hiPSC-CMs from an ARVC patient, (i) NDPK-B and SK4 channels were upregulated, (ii) SK4 channels were activated, (iii) pacemaker activity was enhanced and (iv) the occurrence of arrhythmias was increased. This evidence concerns the gene KCNN4 and Arrhythmogenic right ventricular dysplasia.