El-Battrawy et al. showed that human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) from a patient with ARVC (ARVC-hiPSC-CMs) carrying a mutation in the DSG2 gene displayed multiple ion channel dysfunctions and abnormal electrical activities [6], pointing to the contribution of ion channel dysfunctions to arrhythmogenesis, independent of structural abnormalities. Here, DSG2 is linked to arrhythmogenic right ventricular cardiomyopathy.