In summary, this study revealed that in hiPSC-CMs from an ARVC patient, (i) NDPK-B and SK4 channels were upregulated, (ii) SK4 channels were activated, (iii) pacemaker activity was enhanced and (iv) the occurrence of arrhythmias was increased. Here, NME2 is linked to arrhythmogenic right ventricular cardiomyopathy.