Using 785 MRI data [25] classified progressive MCI vs. static MCI with an accuracy of 86%, using combined MRI, APOe4 genetic data, and available clinical practice variables and cognitive measures including neuropsychological cognitive assessment tests like the Dementia Rating Scale (CDRSB), the Alzheimer’s Disease Assessment Scale (ADAS11, ADAS13), episodic memory evaluations in the Rey Auditory Verbal Learning Test (RAVLT). The gene discussed is APOE; the disease is early-onset autosomal dominant Alzheimer disease.