AMBRA1 and cancer: Indeed, many of the SB-predicted oncogenes are activated by translocations similar to those described for FOXR2. This includes known proto-oncogenes like ERG and RAF1, but many more novel proto-oncogene candidates including AMBRA1 and RALY. AMBRA1 is a regulator of autophagy and has been shown to affect drug resistance in several cancers [115,116,117].