We aimed to analyze <i>HDAC5</i> expression in BCVY and older patients and their correlation with clinical features, also studying the potential of HDAC5 inhibition in BC cell lines.<h4>Methods</h4><i>HDAC5</i> expression in 60 BCVY and 47 older cases were analyzed by qRT-PCR and correlated with clinical data. Here, HDAC5 is linked to breast cancer.