Similarly, AVA and SO treatments achieved normalization of GST and NQO1 activities in the colon, suggesting that both treatments could neutralize the effects of oxidative stress at the colon level, initially generated by the oxidative metabolism of AOM and inflammation induced with DSS and, subsequently, by persistent inflammation in this disease model [75,76,81,82], resulting in a reduced carcinogenic impact. The gene discussed is NQO1; the disease is infectious otitis media.