OLE produced the inhibition of macrophage inflammatory 1 alpha (MIP-α) expression and secretion in MM cells proliferation by inducing the activation of apoptosis mechanisms and by down-regulating extracellular signal-regulated kinase (ERK)1/2 and protein kinase B (Akt) signal transduction pathways [133]. The gene discussed is AKT1; the disease is Miyoshi myopathy.