RRM2B and non-small cell lung carcinoma: For instance, Shi et al. reported that the four enzymes associated with glutathione metabolism, namely glutathione peroxidase 4 (GPX4), aminopeptidase N (CD13), 5-oxoprolinase (OPLAH), and ribonucleotide reductase regulatory TP53 inducible subunit M2B (RRM2B), played an essential role in the chemoresistance of NSCLC to cisplatin [81].