However, although the WP1130-induced increase in ROS levels was observed also in the FLT3-ITD-positive AML cell line MV4-11 [22], it was not observed in CML and mantle cell lymphoma cell lines [16,18], thus suggesting that it may be dependent on cellular contexts. This evidence concerns the gene FLT3 and chronic myelogenous leukemia, BCR-ABL1 positive.