FLT3 and acute myeloid leukemia: However, inactivation of Mcl-1 or its conversion to a pro-apoptotic protein by the cleavage by caspases has also been reported mainly in hematopoietic cells [45,46], and we have previously demonstrated that WP1130 decreased Mcl-1 expression through the cleavage by caspases also in FLT3-ITD-positive AML cells [22].