In addition, we have recently reported that inhibition of USP9X by WP1130 as well as EOAI3402143 (G9) induced aggresomal translocation of the mutant receptor kinase FLT3 internal tandem duplication (FLT3-ITD) expressed in AML cells to block the downstream signaling events and induced oxidative stress, thus cooperatively activating the intrinsic mitochondria-mediated apoptotic pathway, which was synergistically enhanced by BH3 mimetics and prevented by overexpression of Bcl-xL or Mcl-1 [22]. The gene discussed is USP9X; the disease is acute myeloid leukemia.