On the other hand, we have recently revealed that inhibition of USP9X by WP1130 or G9 induced oxidative stress to stimulate stress-related MAP kinase pathways and DNA damage responses, which cooperated with inhibition of FLT3-ITD signaling to induce apoptosis efficiently in FLT3-ITD-positive AML cells [22]. Here, USP9X is linked to acute myeloid leukemia.