CASP3 and cancer: Figure 6 depicts the results for FaDu and normal keratinocytes. SCC9 and Detroit respond similarly (data not shown). Concurrent staining with Annexin-V and 7-AAD detected live cells, early stage of apoptosis and late stage of apoptosis following treatments. Total cell death was significantly distinct between treated (QMTs or cisplatin) and untreated cells (Figure 6A–H). The detection of caspase 3/7 activation following cell treatment confirmed programmed cell death proceeding via caspase 3/7 activation, both for keratinocytes and the cancer cell line (Figure 6I).