Recently, in 968 adult post-cardiac surgery patients from the TRIBE-AKI cohort, Parikh et al. found that the plasma markers for cardiac injury (high-sensitivity troponin and heart-type fatty-acid-binding protein) or left ventricular overload (N-terminal pro-BNP), but not urinary tubular injury markers (IL-18, NGAL, KIM-1, L-FABP, and albumin), were independently associated with increased long-term risk of cardiovascular events [25]. This evidence concerns the gene LCN2 and acute kidney injury.