In the Translation Research Investigating Biomarker Endpoints for Acute Kidney Injury (TRIBE-AKI) study involving 1,199 adult patients who underwent cardiac surgery, Coca et al. showed that higher urinary interleukin 18 (IL-18) and kidney injury molecule 1 (KIM-1) levels were independently associated with 3-year mortality, regardless of the creatinine-defined AKI status [11]. This evidence concerns the gene HAVCR1 and acute kidney injury.