In terms of spinal effects, EGCG decreases TNF-α expression in the spinal cord in mouse models of bone cancer-caused pain [152] and reduces glial cell activation via inhibition of fatty acid synthase (FASN), Ras homologue gene family member A (RhoA), and TNF-α in a model of spinal cord injury (SCI) [153]. The gene discussed is FASN; the disease is spinal cord injury.