CD8A and neoplasm: As a heterodimeric cytokine, it produces multifaceted anti-tumor effects [1,2], including stimulation of growth and cytotoxic activity of natural killer (NK) cells and T cells (both CD4+ and CD8+) [1,3,4,5], induction of differentiation of CD4+ T cells towards Th1 phenotype [6,7], increased production of IFN-γ from NK and T cells [1,8,9], and inhibition of tumor angiogenesis [1,10].