In this study, mice treated with either Ad-ΔB7/IL-12 or Ad-ΔB7/IL-12/4-1BBL have a higher amount of tumor infiltrating CD4+ and CD8+ cells in comparison to treatment with Ad-ΔB7/4-1BBL or Ad-ΔB7 [49]. The gene discussed is CD8A; the disease is neoplasm.