G47Δ-IL12 treatment promotes polarization of macrophages from pro-tumoral M2 towards anti-tumoral M1 (e.g., increased expression of iNOS+ and pSTAT1+ cells) without affecting total tumor-associated macrophage (TAM) population (Figure 5) [19], possibly because of IL-12 induced M1-polarizing IFN-γ expression [30]. The gene discussed is IFNG; the disease is neoplasm.