PECAM1 and neoplasm: Similar to G47Δ-IL12 and anti-angiogenesis studies, the combination of another IL-12 expressing OHSV NV1042 with the anti-cancer chemotherapy drug vinblastine results in significant reduction of tumor burden in athymic mice bearing subcutaneous CWR22 prostate tumors, which is most likely associated with diminishing the number of CD31+ endothelial cells [126].