Of particular notice, treatment of MC38 cells with SFV-IL12 results in tumor-infiltrating monocytic myeloid-derived suppressor cells (M-MDSCs) displaying increased expression of CD11c, CD8α, CD40, and CD86 in the presence of an intact, endogenous host type-I interferon (IFN-I) system [55]. The gene discussed is CD8A; the disease is neoplasm.