Activation of Sirt1 enables the deacetylation of a variety of proteins, resulting in a robust, protective cellular response, as it regulates processes such as cell death, metabolism or neurodegeneration [30]; while Sirt2 has been reported to regulate oxidative stress, genome integrity and myelination and its dysfunction is found in most age-related neurodegenerative disorders such as AD, Parkinson’s disease and Amyotrophic Lateral Sclerosis, as well as in physiological aging [31]. Here, SIRT2 is linked to amyotrophic lateral sclerosis.