MPO and Stroke: This is reminiscent of what was found in other CNS-related disease models: Inhibition of MPO reduces brain damage in a murine stroke model [29], reduces oxidative stress-induced neuronal damage [30], ameliorates experimental autoimmune encephalomyelitis (EAE) disease severity [31], improves inflammatory parameters in 6-hydroxydopamine induced Parkinsonism [32], and increases neurogenesis after ischemic stroke in mice [33].