HCT1026 is endowed with a favourable safety profile and shown to downregulate microglial activation via the inhibition of PHOX and iNOS‐derived RNS, resulting in a significant protection of nigrostriatal DAergic neurons in PD rodent models, in both young and aging mice (L'Episcopo, Tirolo, Caniglia, et al., 2010b; L'Episcopo et al., 2011c; L'Episcopo, Tirolo, Testa, et al., 2010a). Here, NOS2 is linked to Parkinson disease.