TNF and Parkinson disease: In the same years, by using NSC culture techniques, intraventricular tumor necrosis factor (TNF)‐α infusion and the 6‐OHDA mouse model, mimicking PD‐associated neuroinflammation, Worlitzer et al. (2012) showed significant detrimental effects on SVZ‐NSCs, due to a decreased generation of DCX+ neuroblasts, but the signalling mechanism(s) underlying such inflammatory‐mediated detrimental effects were not fully clarified.