Comparison between patients categorized according to biomarker expression, using formula A, i.e. [KLK6/CEACAM5 + SLC35D3/CEACAM5 + POSTN/18S rRNA -MUC2/CEACAM5], with regard to risk for recurrence of disease and cancer death and observed recurrence 3 and 5 years after curative surgery. The gene discussed is KLK6; the disease is cancer.