IMP3 and osteosarcoma: To date, there are three known members of IMP3 family proteins: IMP1, IMP2, and IMP3[6] Expression of IMP3 is negative in normal, mature tissues, but was found as positive in the malignant tumors of the colon, kidney, bladder, pancreatic ductal adenocarcinoma, gastric cancer, non-small cell lung cancer, melanoma, thyroid cancer, osteosarcoma, and breast cancer and related with aggressive behavior of the tumor, advanced clinical stage, and distant metastases.[7–18]